In the novel, there were only a handful of time, when Serina was mentioned. However every time she was mentioned there was always a big impact. Serina was just that type of individual. Beauty, talent, power she held everything and that became the reason for her demise.
The Demons, specifically Eldros a S rank demon that uses curses got a chance to put his curse on her. Eldros was a high ranking demon in the heiarchy even having the power to control SS ranks demons because of his ability. Though this wasn't without a loss for them as they had lost two SS ranks however there gain was far more than losing some demons.
In the novel it was never mentioned when she died, there was only that fact Frosts had done their everything to find him but failed. Also when he appeared again the Frosts were fallen. Giving demon a big advantage as one of the great families fall.
' This...This can be a big opportunity to finish him early and i think we have small debt to settle.'