The first stage could be unlocked by scientific means in some sense. Xuan once said that a poisonous substance could unlocked the constraint. However, only a small quantity of people could survive the poison.
The original T virus could be thought of as a neutralizer to the substance, so that the human body wouldn’t take damage from entering the unlocked state. At the same time, the virus increases muscle density and reaction speed. With these benefits, the human body could unlock the constraint and don’t have to endure the pain. Just like how Alice and Angela was.
This item was invaluable to the players. The newbies’ strength would grow exponentially even if it was just the first stage. Just the ability in using guns would be ten times stronger than normal people.