The loss of control of the Nanomachine Swarm 65 years ago...
The war had been raging on for so long that it was almost impossible to explain what it was all about. It was also impossible to understand who the first provoker of the war was. But, there was at least some consensus among the people that the Nanomachine Swarm, which went berserk, was absolutely the deadliest cause.
The Nanomachine Swarm in the Northern Hemisphere had eroded the protective walls, instantly annihilating three nearby cities. The area that the Nanomachine Swarm ravaged remained a dead zone until now. As the soil and environment changed, no plants could grow. There were highly toxic chemicals and remnants of the Nanomachine Swarm in the water. Less than half of the adventurers who ventured into that area of death came back alive.