Cadeceus is not the biggest realm dominated by men, but it was the most prosperous amongst all. There were about dozens of portals to other realms that dotted the place. Based on the scholar's speculative dimensional bubble map, Cadeceus was in the middle of all. Around it was ten of the inhabited worlds. ('Worlds' being the local terminology and not referring to the universe)
Due to this unique structure, the dimension had became the most important traffic route. Aside from humans who make up fifty percent of the populace, other races had also set up outposts and towns in Cadeceus. Thus when there were conflicts between men, Cadeceus would be bound by absolute neutrality based on some ancient accords, and play the role of a sanctuary.