The third Epic item was Imperial Qiraji Armaments, which was a quest item.
On the journey from the third Boss to the fourth Boss, Frankriss the Unyielding, there were the elite Vekniss Soldiers and the non-elite Vekniss Drones. If they got wiped while fighting them, they would have to start all over again. However, after they killed Frankriss, they wouldn't be able to farm these insects anymore.
But this meant that every time they got wiped, they had to start by fighting these monsters again.
This was a very annoying process in obtaining the First Clear.
Unfortunately, there was no choice. The Instance Dungeon was designed in this way, so they just had to not get wiped.
If they could do it one go, then they wouldn't have to worry about it.