To be honest, Leon was acting rather impulsive by consuming the Mind Concentrating Potion!
According to the process he had understood earlier, a time interval of at least three to four days was required between each intake of the potion. This was so that he could avoid the cumulation of damage. But, because he thought that he was a young, strong and growing man, he decided to take the second potion right after the first. After all, he didn't have the patience to wait.
The consequence brought about by his reckless decision was obvious.
After the first potion, his Physique was only reduced by 0.85, but the second potion had brought it down by another 1.05. If Leon had taken the third potion, perhaps his Physique would've taken a nose dive of nearly two points.