It hurts. That's always the first thought that comes to mind whenever I use magic. In a world where magic is everything, where you need it to survive, what happens is it's also the very thing that's killing you? What's the point of having the most mana in the world if your body tries to reject it at every turn?
This is the Tale of the mage that has to sacrifice his very body and mind to use mana, the Sacrificial Mage, Asura Emlent.