Mystery carries 'weight,' even if it is just a fragment of memory, and the closer to the source, the more apparent this phenomenon becomes.
As previously mentioned, at the level of the world, matter, energy, and information are equivalent to each other, and some things of very high essence also possess similar characteristics. The Rune Scriptures are exactly like this.
When Odin had completed the sacrifice of himself unto himself, and 'picked up' these runes from the Spring of Wisdom—runes which could decipher all things of the world—He thought He could become the master of the world. However, He gradually realized that He simply could not bear the 'mystery's' weight.
If the problem faced by Chaos, the Primordial Gods, was that They could not withstand the continuous assault of the full mighty power and had to walk the world in incarnations to maintain Their personas, then Odin faced a similar issue.