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The company had a whole stack of war preparations, such as the "Bee Poison Potent Extract" we used last time. There's plenty of it in the Eastern Warehouse, and it's the very same stuff we used to wipe out the Oda Family. Worked like a charm.
But "Bee Poison" is essentially just poison, even though it's a genetic-targeting toxin that can be set to "kill the Tokugawas only," sparing the innocent. It still has to be delivered accurately to be effective, so the key is really the method of poisoning.
When the company made its move, it simply pulled the plug on the entire server, sent nanorobots sneaking into the financiers' mansions, and poisoned them one by one.
If Li Pan were to do it now, he'd probably need to consult the operation manual, tweak the "Bee Poison" activation rate, then grab a third-tier member of the Tokugawa Clan, give 'em a shot in the vein, and let them spread it through family transmission. The efficiency of total extermination is another matter entirely.