To refine every tael of Qing Frost, the flesh of two living humans is needed as the alchemical primer. Its method of refinement is incomparably sinister and cruelly blood-stained. The Qing Frost concocted through such means is second in its toxicity—what matters most is there will never be an antidote!
That is the most terrifying aspect of Qing Frost.
In this world, everything has cause and effect, mutually generating and overcoming each other. Every poison, throughout history, has had an antidote concocted. But Qing Frost, after hundreds of years through the entire Medicine Sect, has never been unraveled!
As for the origin of Qing Frost, it was created by the wife of the first Sect Leader of the Medicine Sect.
This first lady of the Sect Leader was a famed poison master of her time, committing innumerable evils and acting vicious and ruthless before she met the Sect Leader. Qing Frost was something she crafted out of boredom.