Michael Wilson / The Legendary Spider-Man: The protagonist of the story, who awakens from an ice prison after 38 years and decides to resume his role as Spider-Man, embracing his responsibilities as a hero once again.
Peter Parker/The Future Spider-Man: The deuteragonist of Book 2 Part 2. When he was 10 years old, he was saved by Spider-Man. Now 12 years old, Peter becomes friends with Michael Wilson. He is kind-hearted and eventually becomes the future Spider-Man. He also becomes the future disciple of Michael Wilson.
Mary Rose Taylor: Michael Wilson's girlfriend and love interest. Formerly Mary Rose Fletcher, she died in an incident back in 1952 but was reincarnated through Michael Power, becoming a new person with a new last name. She is also the sister of Mark Taylor.
Mark Taylor: Formerly Mark Fletcher, he died but was reincarnated and became Mark Taylor. He is the best friend of Michael Wilson and plays an important role in his life.
Chris Hilton: One of the friends of Michael Wilson and one of the wealthiest individuals in the world. He is also a friend of Ben Parker.
Emily Hawkins: Girlfriend of Mark Taylor. She became a half-vampire due to the incident in 1952.
Harry Osborn: The son of Norman Osborn and the best friend of Peter Parker. He is also a rival of the Hilton family when it comes to wealth.
Mary Jane Watson: Peter's childhood friend and soon-to-be love interest. She is kind and brave, supporting Peter in his adventures and eventually playing a significant role in his life.
Ben Parker: Uncle of Peter Parker, he serves as a father figure to Peter after the death of Peter's parents. He imparts wisdom and guidance to Peter throughout his life.
May Parker: The aunt and legal guardian of Peter Parker. She cares deeply for Peter and provides him with love and support. She is also the wife of Ben Parker.
Loe Holloway: The director of S.H.I.E.L.D. and a friend of Michael Wilson.
Maria Hill: One of the S.H.I.E.L.D. members and a trusted subordinate of Loe Holloway. She plays a vital role in supporting the operations of S.H.I.E.L.D. and aiding the protagonists in their needs.