Few times does this happen, few times is Dante's existence threatened, and he simply doesn't care about it.
After all, to him, death is just a temporary inconvenience.
If Dante dies, he will simply come back to life, kill whoever dared to attack him, and continue living as always, beside his wives, without anything stopping him.
The issue here, however, is not about his own survival.
It's not about the threat to his life, but something much deeper and personal.
When the threat is not directed at him, but at someone close, someone he cares about, whether that person has been in his life for a long time or just for a brief moment.
In Dante's presence, any threat to his loved ones awakens something much more dangerous.
The black mist around Dante's body began to solidify, shaping his form, but now there was something different.