Without a doubt, if all those Bone Demons were to escape, it would certainly be bad news for the players.
Although players and monsters are enemies, if all the players were to flee, it goes without saying that the players would then lose their Monster Hunting locations. In such a scenario, without enough monsters to provide them with the Experience needed for leveling up, the players' strength would permanently stagnate at a certain level.
Therefore, whether it's players or NPCs, I believe none would give the Bone Demons and other monsters the opportunity to flee, and making deployments in the territories of these monsters would naturally not be surprising.