In the Spheric Verse, it was believed that true cultivation didn't start until one reached the Third Sphere, a Sphere Tier that represented the Body. It was in this Sphere one began to strengthen their bodies using any means possible.
In Damian's case, the Vital Sun Fruits had been what he relied on. While the Holy Waters had being a major catalyst in elevating his Constitution, the truth was that, the Vital Sun Fruits had played a major role as well. It was the combination of the essences of these two resources that propelled his Constitution forward, prepping his physical frame for the Fourth Sphere.
But then, if the Third Sphere allowed one to strengthen the body, what was the Fourth Sphere meant to do?