The fragility of mortality.
Most would think that becoming a denizen of the Immortal Wheels would allow one to break that unfortunate barrier and indeed, most lucky enough to embark on the path to godhood hoped for immortality above everything else.
Alas, it was not to be so.
It was almost like a cruel work of fate, orchestrated by some greater being which some postulated to be whomever was behind the Will of the World.
Most Immortal Wheel Mystics that hadn't achieved divinity died early with average life expectancy reaching a meager 120 years, which was a paltry sum compared to 400 for the Mortal Wheels or even 150 for normal humans.
Even those that did achieve divinity which provided longevity would fall prey to madness ensuring that they wouldn't be able to enjoy a long life.