What's the difference between the Mortal Ascending Ranks and the true ascender ranks?
Everyone has their own answers, but all would agree on one point. Mortal Ascending ranks are where you reach the full potential of your physical body.
Whereas from Master ranks, one has techniques that can accomplish feats beyond their physical limits, by tampering the fabric of reality. These techniques are called Skills.
The simplest explanation of skills is to think of them as weapons.
If you think of Mortal ascender as a normal human, then Master rank ascender will be a normal human with a sword in his hand.
Both are human, but the presence of the sword creates a qualitative difference in their combat ability.
A normal punch won't be fatal unless you aim it at weak points, however for a sword, it's the opposite. Even a slight graze by a sword can leave grievous wounds, and a single swing that has landed on the enemy is deadly.