When her madness, like she would call it, began, various methods were adopted to make her sane permanently, but typically it only made her sane temporarily.
First, they, Roman and Fay adopted soothing music which led them nowhere as it made her destroy things. Her house was a mess during that time, and she did not have to bother about visitors because no one cared to visit, not even Eleanor.
Roman would continually try to calm her down while the music played or even when it was not playing, to no avail.
One day during her usual display of madness, she broke her mirror and while looking for something else to toss around, she stepped on it. The pain went through her leg, up to her head, then went back to her feet.
Then she regained herself.
That became the next method to make her sane. Pain.