Every single rune is like a single point along a river.
As the river flows, each point leaves its trace along the riverbed. However, the flow will never be uniform.
As such, the flow at each individual point would be unique as well. And because the river continues to flow, these flows constantly shift into new points, creating a paradox Cain had personally dubbed the 'Shifting Nature of Runes'.
Because of their nature, there existed and endless possible combinations of runics symbols to create either new runes, or magic circles.
However, this didn't mean that magic couldn't be replicated.
In fact, repetition of certain runic combinations was a rather common occurrence. It was not unusual for different individuals to come up with the same solution to a particular problem.
For example, to cause a liquid to change into solid matter using magic, a special set of runes known as the freezing runes will be invoked.