Holding one's breath directly at this moment has the best effect.
But for a human, even if they can resist from dying due to self-detonation at this moment, it's impossible to hold their breath for a long time.
However, Jia Yan can hold his breath for an extended period. His body showed signs of long-term oxygen independence when he was under the sea. Yet in this mutation, there were other changes, specifically after obtaining the metal from that UFO, his body underwent a direct transformation!
Even without air, apparently, a form of substance clinging to his body generates oxygen. Thus Big Mosquito didn't show any signs of oxygen deficiency. Even if he genuinely couldn't get oxygen, his ability to hold his breath could guarantee about an hour without breathing!
