Flesh Calamity was divided into Flesh Destruction, Flesh Enhancement, and Flesh Reconstruction.
Flesh Destruction involves the shattering of your muscles and the rupture of your internal organs. The more muscle fibers were shattered and the more your organs ruptured, the greater your vitality would need to be to resist. If your vitality was weak, you would perish.
Following that came Flesh Enhancement, in which you began to flood your shattered muscle fibers and ruptured organs with Astral Wave. The more energy you manage to pack inside those wounded tissues, the better.
Finally, there was Flesh Reconstruction, in which you used the energy in your tissues to regenerate them, making them more powerful than before.
This was the normal procedure, and while there were variations, they were still within the norm. Yet, Cain had destroyed his flesh and blood to the point he was just a skeleton, and his tissues were now floating around his bones inside bubbles.