Pain.
No matter how strong one was; if one was not used to pain, then even the mightiest of heroes would fall, or in this case, a villain.
Sophie Palmer– classified as a Threat Level 5 supervillain by the Government. But in terms of strength, she was definitely bordering on Threat Level 6.
There were 7 Levels of supervillains– theorized by the people, then confirmed by the Government. As said by Katherine in one of their lessons.
Level 1 were just considered a nuisance; those who misuse their powers to wreak minor chaos, but not enough to cause damage.
Level 2 were those to be considered street-level, those who use their powers to commit petty crimes like theft, robbery, and minor assault.
Threat Levels 1 and 2 could be dealt with by the normal police with no problem at all. And sometimes, superheroes were discouraged to engage with such individuals, and in some cases, even restricted.