Dealing with poison was always dangerous, even if one was knowledgeable about it. Even those people who possessed resistance against it were not completely safe.
It is important to understand that resistance is not the same as immunity. It's a fine line, a delicate balance that can mean the difference between life and death.
Kyran was resistant to poison to a certain degree. This was because all Regis had to consume several kinds of poison in their childhood to build their poison resistance. They did it in preparation for entering the Regis inner forest, where several beasts— rare, mythical, and special types— that produced poisonous attacks could be found. These beasts were not meant to be killed. They were meant for a Regis to tame.