In boxing, there were few things as dangerous as getting hit in the chin continuously, not because a boxer's body couldn't take the punishment; but because their brains could not tolerate the consequences of such attacks.
Those blows shook the skull with such force that they sent the brain bouncing viciously inside the boxer's head, which could not only directly knock out a fighter but also severely damage brain tissue.
In Tae Kwon Do, a reasonably advanced kicking technique consisted of striking the opponent's skull with terrifying precision and coordination on three separate occasions on opposite sides of the head, looking precisely for this weakness.
In fact, what Desmond had done just now was essentially an unorthodox adaptation of said technique. Needless to say that only a bloody monster like Desmond could pull off a move like that using an improvised weapon while using staff techniques.