A couple of problems ensued right after Elise drank from the goblet that wiped away her memories. It was something that Dante failed to take into account when he gave it to her because he trusted that Elise would be alright.
Elise was already an immortal when she drank from the goblet so Dante was confident that the effects of the water was not enough to render her immobile or in a state of weakness. However, Dante was wrong.
Elise didn't wake up after an hour, hours, and not even after a day or two.
Dante, who had been excited about living and spending his entire lifetime with Elise didn't consider how valuable memories were. Even one drop of the water of forgetfulness was completely potent.
Elise who became an immortal had her memories completely wiped out and it threw her into a coma.