Unfortunately, depending on whether it was a One-Stripe Purple-Gold Pill, a Three-Stripe Purple-gold Pill, or a Six-Stripe Purple-gold Pill, the rarity of the ingredients needed to concoct these pills would also increase exponentially.
On top of that, it would only be effective the first time it was taken. If one were to take it a second time, it would only have half the effect. On the third time, it would be halved again. In the end, there would be no effect.
In the words of modern research, it meant that the body had developed drug resistance, so the effect would naturally be weakened. For example, Body Refining Pills. If he took it now, the effect would not be comparable to when he had been in the Physical Stage and would only be considered slightly useful.