Chereads / Rebirth of humanity savior / Chapter 28 - Genome Editing

Chapter 28 - Genome Editing

(30 July)Ben's one-room apartment was perfect for his uses. It was already furnished, didn't cost a lot, and was near his school.

Ben began opening the boxes, he checked the content and was satisfied. It wasn't a given to receive the order like this time, every dark web market tried it's best to build trustfulness, but as nobody did know the identity of the other there wasn't any repercussion and everyone could scam you.

Ben wasn't a genetic expert in his last life, but he remembered the main concept and common mistakes of editing the genome. Coupled with his well-trained skill, Ben was fully confident to succeed in his first biohacking.

In the following days, began to produce the RNA-guides.

The human genome is made up of some 20 300 genes, all of which may present genetic variants or alleles. Humans always had one of the smallest genomes, for example, a mouse had 30 000 genes.

As with genome size, having more protein-coding genes does not necessarily translate into greater complexity. This is because the eukaryotic genome has evolved other ways to generate biological complexity.

Much of this complexity derives from how the genome "behaves," or more precisely, how various genes are expressed.

This proves that humans could easily change their genome to a greater complexity by increasing its amount of genes, but this is not the focus of Ben's work.

Just as some people have green eyes while others have brown or blue eyes, or that some are taller than others, individual variations due to genetic influences can also be far-reaching and can be found not only in physical traits but also in psychological ones, including those related to cognitive functions.

To give another example, several genes whose alleles differently influence working memory have also been reported.

The environment, including the educational one, is also a significant factor that can allow them to make the most of their capabilities, including intellectual and emotional aspects. In other words, although the brain is malleable and can be changed through education and daily experiences, and thus so can cognitive functions, its formation and functioning are based on a genetic substrate that influences it to a moderate or high degree.

Ben's one-room apartment was perfect for his uses. It was already furnished, didn't cost a lot, and was near his school.

Ben began opening the boxes, he checked the content and was satisfied. It wasn't a given to receive the order like this time, every dark web market tried it's best to build trustfulness, but as nobody did know the identity of the other there wasn't any repercussion and everyone could scam you.

Ben wasn't a genetic expert in his last life, but he remembered the main concept and common mistakes of editing the genome. Coupled with his well-trained skill, Ben was fully confident to succeed in his first biohacking.

In the following days, began to produce the RNA-guides.

The human genome is made up of some 20 300 genes, all of which may present genetic variants or alleles. Humans always had one of the smallest genomes, for example, a mouse had 30 000 genes.

As with genome size, having more protein-coding genes does not necessarily translate into greater complexity. This is because the eukaryotic genome has evolved other ways to generate biological complexity.

Much of this complexity derives from how the genome "behaves," or more precisely, how various genes are expressed.

This proves that humans could easily change their genome to a greater complexity by increasing its amount of genes, but this is not the focus of Ben's work.

Ben planned to mix his DNA with a powerfull beast, but he didn't know which one he should chose.

If you are wondering why Ben accepted such thinking, it was because all the negative emotions he felt from that time (Anger, helplessness, loneliness, anxiety), that he didn't care what he became. Even if he became the greatest devil of humanity as long as he had the power to protect what he always hold dear, he wouldn't care.

The world is cruel to survive in it you have to become yourself cruel. This was the truth that he learned about this world. A transhuman was just a small step to the monster he could become.

Just as some people have green eyes while others have brown or blue eyes, or that some are taller than others, individual variations due to genetic influences can also be far-reaching and can be found not only in physical traits but also in psychological ones, including those related to cognitive functions.

To give another example, several genes whose alleles differently influence working memory have also been reported.

The environment, including the educational one, is also a significant factor that can allow them to make the most of their capabilities, including intellectual and emotional aspects. In other words, although the brain is malleable and can be changed through education and daily experiences, and thus so can cognitive functions, its formation and functioning are based on a genetic substrate that influences it to a moderate or high degree.

So what is CRISPR?

CRISPR utilizes an enzyme called Cas9 that uses an RNA molecule as a guide to navigating towards its targeted DNA. It then edits or modifies the DNA which can deactivate genes or insert the desired sequence to achieve a behavior. In the last years of research, CRISPR has been further improved and doesn't have the flaws it had in 2020.

Wiebor is a synthetic substance, which is not yet widely known in genetic. In the future, a receipt is found with Wiebor as one of its ingredients to reprogram all the specialized cells back to a stem cell state. The substances needed for this receipt were all in Ben's order. Without the reprogramming, the body would not change to the new DNA and would fight with the edited cells.

The human genes, which Ben has ordered, are in his opinion the most worthy genes to replace his own. There aren't really better genes, there are only genes that are more helpful in certain environments or situations.

The first-gen, qLRP5, increases bone mineral density.

The second-gen, hDEC2, leads to the familial natural short sleep behavioral.

The third-gen, MOGS, strengthens the immune system.

The last genes, DRB1; LPA; APOE, and CHRNA3, extend the lifespan about 8 months and lower the risk of autoimmune diseases.

The most popular gen-modification was to deactivate the gen, which controlled muscle growth.

From the viewpoint of Ben, this was the stupidest idea that some researchers had. The evolution gave humans this gen because it was important to regulate muscle growth.

More muscle cells mean more weight and energy needed to sustain the body. To many muscle cells also means to have lower flexibility. An increase in the stat strength would not increase the muscle mass, but it would increase the density, vitality, and complexity of the muscle cells.

There were naturally other good gens. Some of these were the gens, which improved the intelligence, but Ben wasn't clear if he would have side effects or no more being his stupid-self.

The others were gens, which can be very helpful on earth but will decrease in value in another world like the gen, which gave immunity against HIV. An otherworld has other viruses and bacteria.

...

10 Days later, Ben finished incubating the RNA-guides.

He then attached the RNA-Guides to a Cas9 cutting protein and injected himself the liquids. Each of the liquids was injected in its specific place.

After the injections, Ben took the black powder he created from the receipt, which he compressed in a black pill.

From now on he has to take it every day till the genome editing is finished. If stopped taking it, his body would try to get rid of his modified cells and his injections would just have caused him pain.

In the following 100 days, Ben studied and trained hard, he also read all the books and videos about survival.

He had his first exams this year. The next holidays were just at the next corner. He informed his parents that he enrolled in Survival Training School of California for one and a half months.

Like what Ben expected, his parents wanted to stop him, but as Ben already paid for the flight and the training they accepted it, seeing their son being so mature to take his own decision, they felt slightly proud of their education. Ben naturally tried his best to comfort them.