Niklaus and Sakuzi were like fire and ice, they couldn't and would never coexist with each other . Kay issues set aside, there was a reason why Nik had to avoid love at all cost.
The Spencer family were in constant danger because of the nature of their business , potential competitors whether legal or illegally would go to any length just to bring them down .
So using their love interest to blackmail or threaten them was a common occurrence which never bothered Niklaus cause he had no real feelings for his playthings.
But unfortunately he has being captured by cupid's arrow even though he wouldn't admit it, but just caring for Maya alone has created an avenue for his enemies to step in and not just his enemies but his enemy of all enemies - Sakuzi
Nik's bad blood with Sakuzi wasn't something that could be resolved with mere words of apologies but with the death of one of them - two alphas can never exist in a pack, one has to submit or die.