The body that was reformed due to a potion finally started to break down. Adrian knew that it would be the case even if Cristobal used the ultimate binding agent which is the blood of an Asmodian. Cristobal or rather the entity inhabiting Cristobal's body might have succeeded if he opted to become a mutant rather than a perfect Asmodian.
The reason for the body breaking down is simple. The reason being the blood of an Asmodian is perfect as they are the first creatures. Only fellow Asmodians or descendants of Asmodians could ingest said blood to become a version of the perfect being.
Adrian always asks Jianna about alchemy whenever he buys potions from her. Adrian curiously asked what would happen if Asmodian blood is mixed with ingredient. Jianna's answer was it could either become the greatest potion that could revive the dead or the greatest poison that leads to death.
