The Anubis explained how the Depraved Man's Hand is created and Adrian paled when he learned the process. The Depraved Man's Hand is created by having a killer that ended innocent lives become a living saint by other people. The killer must be worshipped until they die as their body is preserved.
There would then be one ritual sacrifice for at least one hundred years where innocent lives are used. The Depraved Man's Hand will become more powerful as long as the ritual is still performed. When the artifact creator is satisfied then they would wrap the hand of the killer in special fabric that can preserve the energy of the faith given to it.
"The fact that something like the Depraved Man's Hand was made in the mortal realm is truly worrying and it has been undetected by even the other gods of death. The only plausible reason for this to happen is that a god is the culprit." The Anubis stated.