Killing General Grimm was easy.
It wasn't even a fight to begin with. Mark didn't have to lift a finger to be honest. The General just toppled over and his core just exploded.
General Grimm already has the Crimson Affliction even before Mark began spreading it. Mark planted a seed on Grimm's core as a parting gift, knowing that one he will certainly kill him. And it did kill him.
The poor General had no idea that he been carrying a seed of Crimson Affliction which was feeding on him for more than a year at this point. It is no surprise that he just straight up died when Mark triggered it since the seed has long since been ready.
As the general's corpse gradually withered where the broadcast took place, the seed that had been triggered on his body left a permanent mark on the place.